Babesiosis ho lintja: phekolo

 Bakeng sa phekolo ea lintja tse nang le babesiosis, palo e kholo ea meriana e fapaneng e 'nile ea lekoa ka liphello tse fapaneng. 

Leha ho le joalo, li-derivatives tsa diamidine tse sebelisetsoang ho phekola canine babesiosis (bernil, batryzin, verbiben, azidin, joalo-joalo) li na le ts'ebeliso e pharaletseng e sebetsang. Motsoako o sebetsang oa lithethefatsi tsena ke diminazene aceturate. Azidine e na le 100% ea motsoako o sebetsang. Berenil e hlahisoa ka mokhoa oa granules, 23,6 g ea eona e na le 10,5 g ea ntho e sebetsang. Batrizin e hlahisoa ka mokhoa oa granules, 10,5 g ea eona e na le 4,66 g ea ntho e sebetsang. Veriben e hlahisoa ka mokhoa oa granules, 2,36 g ea eona e na le 1,05 g ea ntho e sebetsang. Azidine, berenil le batryzine ke tsa sehlopha "B" mabapi le chefo. Tekanyo e phahameng ea lithethefatsi bakeng sa litoeba ke 40 mg / kg, bakeng sa mebutlanyana - 25-30 mg / kg, lintja, likhomo le lipere - 10 mg / kg. Lithethefatsi ha li na phello e phatlalalitsoeng ea ho bokellana, empa ka litekanyetso tse phahameng li baka chefo, e tšoauoang ke pherekano mosebetsing oa tsamaiso ea methapo e bohareng: tonic convulsions, ataxia, 'me ka linako tse ling ho hlatsa. Veriben ke ea metsoako e chefo e itekanetseng bakeng sa liphoofolo tse mali a futhumetseng. Sethethefatsi sena se bokellana haholo-holo sebeteng le liphio, ka tekanyo e nyenyane bokong 'me se ntšoa haholo-holo ka moroto. Ketso ea lithethefatsi e thehiloe ho thibelo ea aerobic glycolysis le DNA synthesis ho pathogenic protozoa, phello ea sebopeho se setle le ts'ebetso ea lisele tsa lisele. Likokoana-hloko tse hanyetsanang le berenil ke ntlha ea bohlokoa ea ho phela ha lintho tse phelang. Motsoako oa bobeli oa diamidine, o sebetsang hantle khahlano le B. canis, le mefuta e meng ea mafu - pentamidine, e sebelisoa ka tekanyetso ea 16,5 mg / kg habeli ka nako ea letsatsi le letsatsi. Ka tšebeliso ea eona, litla-morao tse kang bohloko sebakeng sa ente, tachycardia, ho nyekeloa ke pelo le ho hlatsa lia khoneha. Setlhare se sebetsang hantle haholo khahlanong le B. canis ke imidocarb (e nkiloeng ho carbanilide) e sebelisoang ka tekanyo ea 5 mg/kg. Ho ea ka bangoli ba bang, berenyl le azidine sterilize 'mele oa liphoofolo ho tloha piroplasmids le ho thibela babesiosis ha e tsamaisoa 5-10 esita le matsatsi a 17 pele ho tšoaetso. Ho latela DA Strashnova (1975), berenil ka tekanyo ea 7 mg/kg ea boima ba 'mele e thibela tšoaetso ea lintja tse nang le pathogen B. canis nakong ea matsatsi a 15. Leha ho le joalo, tsamaiso ea berenyl bakeng sa merero ea prophylactic ka nako e le 'ngoe le mali a hlaselang ha ea ka ea bolaea' mele oa lintja ho tloha B. canis, empa, leha ho le joalo, ho ata ha pathogen maling ho fokotsehile haholo. Ho fokotsa ts'oaetso ea mafu ka lebaka la ts'ebetso ea bohlokoa ea likokoana-hloko le lefu la bona la boima ka mor'a ho tsamaisoa ha lithethefatsi tse khahlanong le lesea, hammoho le ho fokotsa liphello tse chefo tsa lithethefatsi tsa protistocidal, phekolo e fapaneng ea matšoao e lokela ho sebelisoa. Bakeng sa ho ntlafatsa ts'ebetso ea pelo, ho sebelisoa litokisetso tse fapaneng tsa pelo. Hangata, sulfocamphocaine e sebelisoa ka mokhoa oa tharollo ea 10% ka tlas'a letlalo kapa intramuscularly ka tekanyo ea 1,0 ml ka 20 kg ea boima ba ntja. Setlhare se tsamaisoa ka makhetlo a 1-2 nakong eohle ea kalafo. Litlhare tse ling tsa pelo (riboxin, cordiamin, camphor) le tsona li sebelisoa. Ho fokotsa botahoa ka kakaretso, ho sebelisoa gamavit ea lithethefatsi, e nang le motsoako o leka-lekaneng oa physiologically oa li-amino acid tse 20, livithamini tse 17, likaroloana tsa nucleic acid, trace elements, hammoho le placental extract le immunostimulant (sodium nucleinate). Lipontšo tse ka sehloohong tsa tšebeliso ea gamavit ke thepa ea eona e le detoxicant, e etsang bonnete ba ho se nke lehlakore le ho tlosoa ha lihlahisoa tse bolileng tse chefo, le ho etsa hore mesebetsi e khathatsehileng e be e tloaelehileng ka lebaka la ho pepeseha ha bona. Gamavit e kenya letsoho ho tsosoloseng ts'ebetso ea hematopoietic ho babesiosis. ₉) le L-glutamic acid, e ameha ho boloka hematopoiesis. Setlhare se lokela ho tsamaisoa ka mokhoa o ka tlase ho tekanyo ea 0,1 ml / kg ea boima ba 'mele ka matsatsi a 5-7. Hangata, edema ea likarolo tse fapaneng tsa 'mele ho lintja le ho tsoa mali ka har'a mucous ho na le tšimoloho e ts'oanang mme e bakoa ke ho eketseha ha vascular porosity ka lebaka la ho pepesehela chefo. Ho tsosolosa botšepehi le ho thibela tlōlo ea marako a vascular, etamsylate (dicinone) e sebelisoa ka mokhoa oa 12,5% ea tharollo intramuscularly. Lithethefatsi li tsamaisoa ka tekanyo ea 1,0 ml ka 20 kg ea boima ba 'mele hang ka letsatsi bakeng sa matsatsi a pele a 2-3 a phekolo. Meningeal liketsahalo tse ngolisitsoeng ho lintja tse ling mohlomong li bakoa ke nts'etsopele ea microflora e nkang monyetla ka lebaka la ho fokotseha ha khanyetso ea phoofolo e kulang. Ka hona, ho thibela ho hlaha ha matšoao ana a rarahaneng, hoa hlokahala ho sebelisa li-antimicrobial agents. Ho ipapisitsoe le sena, liente tsa letsoai la sodium la benzylpenicillin li lokela ho kenyelletsoa nakong ea kalafo ea babesiosis ho thibela liketsahalo tsa meningeal ho lintja. Lithethefatsi li tsamaisoa ka intramuscularly ka tekanyo ea li-unit tse likete tse 10-15 ka kg ea boima ba 'mele ka lihora tse ling le tse ling tse 6, ho qala ka tekanyo ea pele ea phoofolo, nakong eohle ea phekolo. Li-antihistamine le corticosteroids (dexamethasone, prednisolone) li sebelisoa ho fokotsa karabelo ea ho ruruha ka kakaretso. Hoa tsebahala hore tšebeliso ea nako e telele ea corticosteroids e ka baka tlōlo ea metabolism ea metsi-sodium 'meleng kapa ea lebisa ho thibela mosebetsi oa adrenal cortex. Ka hona, e le ho qoba liketsahalo tsena, matsatsing a mabeli a ho qetela moriana o tsamaisoa ka litekanyetso tse fokotsehileng. Ho boloka ts'ebetso ea sebete ho lintja tse kulang, Essentiale forte e boetse e sebelisoa ka tekanyo ea 3-5 ml phoofolo ka 'ngoe ka methapo ka matsatsi a 5-7.

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